Inhibin A testing

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

Introduction

Inhibins are dimeric glycoproteins composed of an α-subunit and either a βA (inhibin A) or a βB-subunit (inhibin B). The inhibin α-subunit has N-linked glycosylation sites and the glycosylation is essential for inhibin bioactivity (FSH suppressing activity). Inhibins are mainly produced in gonads and provide negative regulation of FSH secretion, but also have paracrine/autocrine actions in gonads and adrenal gland. As they sharing the β-subunits with activins, it is now recognized that actions of inhibins are associated with their antagonism of activin signaling. Inhibin A consists of an α-subunit and a βA-subunit.

 

 

 

 

 

Benefits of Inhibin A testing

 

It is intended for in vitro use as an aid in the diagnosis and monitoring of various hormonal reproductive disorders. Down syndrome (Trisomy 21) screening in the 2nd trimester using combined biochemical and ultrasound markers may be assessed with appropriate algorithms that can be run on commercially available risk calculation software.  It is strongly recommended to use validated software designated specifically for evaluating the risk of Trisomy 21. The Inhibin A kit is intended for use in combination with hAFP + hCG + uE3.

 

 

 

 

 

DiaSino Inhibin A advantages

 

Easy: ready to use reagents across whole kit, without any preparation

Fast: two-step sandwich principle, only 140 minutes assay time

Reliable: intra-assay: CV ≤ 7.29%, and inter-assay: CV ≤ 8.12%

Accurate: clinical correlation to Beckman Coulter Inhibin A ELISA up to r ≥ 97% on 89 clinical samples

Specific: the monoclonal antibody pair used in assay is highly specific to INHA